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posted by E. James Schermerhorn
This is the biennial Buck-Whitney Award meeting at which the awardee will honored. For details on the Buck-Whitney Award.
Moscatiello's Restaurant, Troy NY
Click here for directions
Parking - Available behind the restaurant
Yimon Aye, Ph. D.
Howard Milstein Faculty Fellow and Assistant Professor, Chemistry & Chemical Biology
ABOUT THE SPEAKER:
Yimon Aye was born and raised in Burma. She moved to the UK to study for sixth form (high school) and then read chemistry at Oxford University, UK. She moved to Harvard University, USA, achieving a Ph.D. in organic chemistry under the supervision of Prof. Dave Evans. She then moved to Massachusetts Institute of Technology to research the cellular and biochemical regulatory mechanisms of the enzyme ribonucleotide reductase with Prof. JoAnne Stubbe. In her independent career at Cornell University that began in mid-2012, she set out to understand the detailed mechanisms of redox signaling. This impetus culminated in the development of T-REX. In a parallel research program distinct from redox regulation, she studies proteins/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents in clinical use. www.ayelab.org
"Translating the Precision Electrophile Signaling Code"
Precisely timed and spatially regulated electrophilic chemical signals are the essence of biochemical redox signaling. However, defining the precise biological impacts of localized signals that engage with specific protein targets under physiologic conditions has proven to be highly challenging. This talk presents a unique set of proximity-directed chemical tools that enables interrogation into functional consequences of specific redox events through precision electrophile targeting in living systems. With this in vivo-validated redox-targeting toolset, we identify bona fide "first responders" that interact with native signaling electrophiles under electrophile-limited (true kcat/Km) conditions. Our data illuminate these first responders as novel signaling nodes, interchanging electrophile and conventional signaling codes such as phosphate and ubiquitin for decision making at organismal level. Our unique chemical biology toolset sets the stage for ruling in gain-of-function (or dominant loss-of-function) electrophile signaling events at single-protein-target resolution and relating them to phenotype in an unbiased experiment that is not hampered by functional redundancy.
5:30 - 6:15 – Registration and networking
6:15 - 7:00 – Dinner
7:00 - 7:30 – Business Meeting
7:30 - 8:30 – Seminar & Award Ceremony
Please make dinner reservations by Monday, November 13, 2017. Click here to register for the meeting. Please note that pre-registration is required and ENY ACS events are cashless.
Dinner will be $25 per employed attendee, $15 for full-time graduate students, and $10 for undergraduate students, retired and unemployed attendees.
Cheese and crackers, ziti primavera, portobello ravioli, meatball and sausage, chicken marsala and mini cannoli